rare variant risk_factor_for psychiatric disorders

results from studies of copy number variants (CNVs) ... important effects on psychiatric disorders

multiple rare variant model suggests rare variants contribute to psychiatric disorders

rare variants may have larger effects ... likely that the major psychiatric disorders result from the combination of variants

substantial risk that some rare variants confer ... implications of these variants on clinical management of psychiatric conditions

the SNP heritability does not explain all of the estimated additive heritability, suggesting that ... rare variants, also contribute

studies of CNVs and rare SNPs will also be critical in elucidating disease mechanisms