Alcohol exposure had a significant effect on the methylation of genes important for olfactory reception 104 genes in ALC-NTC and 98 genes in ALC-NTO (see Suppl. S3), and most of these are LCP genes. Olfactory gene methylation would be consistent with observations that subjects exposed to alcohol prenatally are more likely to associate alcohol odor with memory.59–61 Furthermore, quantitative trait locus (QTL) analysis on alcohol-differentially vulnerable C56/BL6 and DBA2 recombinant inbred (BxD) mice showed a cluster of olfactory receptor genes to be candidate alcohol-sensitive genes (personal communication, Chris Downing, and our unpublished observation).
