Table 1 presents descriptive statistics for study variables for males, females, and each racial/ethnic group. Males had a higher prevalence rate of cigarette [χ2 (2) = 7.64, p < .05] and marijuana [χ2 (2) = 14.82, p < .01] use. Racial/ethnic groups differed for cigarettes [χ2 (4) = 35.14, p < .001] and prescription drug [χ2 (4) = 26.16, p < .001] use. Follow-up analyses showed that Caucasian adolescents had a higher lifetime prevalence of prescription drug use than Hispanic/Latino youth [χ2 (2) = 6.56, p < .05] and a higher lifetime prevalence rate of both cigarette [χ2 (2) = 33.96, p < .001] and prescription drug use [χ2 (2) = 25.66, p < .001] than African American youth. Hispanic/Latino adolescents had a higher lifetime prevalence of both cigarette [χ2 (2) = 23.20, p < .001] and prescription drug use [χ2 (2) = 8.18, p < .05] than African American youth.