A benefit of the modeling is that the Po over time of each BK cluster can be calculated. As is evident in Fig. 7 A, the IBK generated by the nearest cluster to the RYRs followed more closely the rise of [Ca2+], with a Po reaching 0.4 at the plateau. For BK clusters further away from the RYRs, the resultant IBKs rose with a delay compared with the corresponding [Ca2+], and the Po of these channels reached only ∼0.2 and 0.1.
