Notably, prior G×E research on alcohol use outcomes primarily focused on adolescents and young adults, and limited research has examined G×E influences across a broader age range of adulthood (Su et al., 2021). This study examined potential developmental differences in the role of alc-PRS and social support in alcohol use across the adulthood years. For EAs, the main effect of alc-PRS on alcohol use appears to be fairly consistent across adulthood. This appears to be inconsistent with prior evidence that heritability of alcohol use increases from adolescence to adulthood (Dick et al., 2007; Kendler et al., 2008). The inconsistent findings may be due to different methodology (twin studies vs. polygenic scores). The limited predictability of alc-PRS in the present study may also have hindered the detection of developmental differences. Alternatively, this may be due to the fact that our sample was comprised of high-risk adult alcohol users, the majority of whom may have established their drinking patterns and thus genetic influences on their alcohol use may be more stable. Future research is needed to further examine developmental changes in polygenic
