AAs in genetic research to better characterize genetic risk among this population. Additionally, we note that alc-PRS for AAs were generated for the AUDIT-C while alc-PRS for EAS were generated for drinks per week, which matched more closely to the outcome of the present study. Prior research indicates that PRS prediction is the strongest with matched phenotypes between the discovery GWAS and the target sample (Docherty et al., 2018). Thus, it is possible that the reduced predictability of alc-PRS among AAs in our sample could be due to the mismatch in phenotypes between the discovery GWAS and the current study.
