To partition the SNP-based heritability of general risk tolerance, we used stratified LD Score regression50, following the procedure described by Finucane et al.50. We estimated stratified LD Score regressions both for the functional genomic regions of the “baseline model” and for the tissue-level annotations provided by Finucane et al. To correct for multiple hypothesis testing, we applied a Bonferroni correction for 52 two-sided tests in the baseline model (i.e., for 52 annotations) and for 10 two-sided tests in the tissue type models (i.e., for 10 tissue types).
