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Chunk #90 — ONLINE METHODS: — Biological annotation: additional bioinformatics analyses

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
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We also used DEPICT33 (release 194) to prioritize tissues, gene sets, and genes that are implicated by our GWAS results. Only SNPs with GWAS P values less than 10–5 were used as input, and DEPICT-defined loci were defined by clumping these SNPs (see the Supplementary Note for the clumping parameters used for this analysis). Locus boundaries were then defined using a LD r2 threshold of 0.5, and overlapping loci were merged, yielding 464 autosomal loci comprising 1,060 genes.