We conducted a series of additional bioinformatics analyses using the results of the combined meta-analysis of our discovery and replication GWAS of general risk tolerance. We conducted a gene analysis with MAGMA31 to test each of 18,224 genes for association with general risk tolerance in a hypothesis-free manner (the 18,224 genes are the set of all genes containing at least one SNP in our combined meta-analysis results). We used our main reference panel to estimate LD. Bonferroni correction was applied to account for multiple testing, counting each gene as an independent test. We then used the Gene Network32 co-expression database to gain insight into the functions of the significant MAGMA genes.
