The groups were similar on most demographic characteristics (Table 1). As expected, the HD were higher than the LD on alcohol drinking and related variables, but liver enzyme levels did not differ between groups. The HD also had fewer years of education and higher disinhibited personality trait scores than the LD, both of which were included as covariates in all analyses. In the laboratory sessions, the BrAC changes over time confirmed the expected pattern of ascending and descending limbs. Although the HD exhibited higher BrAC at the high dose than did the LD (group×dose×time: F5,940=3.43; P<.01; Figure 1A), the difference between groups was small (range, 0.001–0.008 mg/L at various time points), and covarying for BrAC did not alter the main findings.
