Alcohol dose-dependently increased self-report ratings of feel drug (Figure 1B), with the LD more sensitive than the HD at the high dose of alcohol (group×dose×time: F6,1128=4.57; P<.001). However, the groups differed markedly in the nature of their alcohol responses. The HD reported greater positive and rewarding subjective effects of alcohol than the LD, particularly at the high dose (Figure2A–C). High-dose alcohol significantly increased Biphasic Alcohol Effects Scale stimulation ratings in the HD vs the LD during the early, ascending limb of the BrAC (group×dose×time:F8,1504=3.21; P=.001)and both like and want more ratings throughout both limbs (group×dose: like, F2,376=15.68; P<.001; and want more, F2,376=12.04; P<.001). Furthermore, the low dose of alcohol also increased ratings for like and want more in the HD vs the LD(Figure2).
