Increases in Biphasic Alcohol Effects Scale sedation were noted in both groups after alcohol consumption, with the LD reporting higher sedation than the HD throughout both BrAC limbs after the high dose (group×dose×time: F8,1504=4.87; P <.001; Figure 3A). Sedation also increased after the low dose, albeit to a lesser extent than with the high dose, with higher ratings in the LD vs the HD at peak BrAC. Increases in salivary cortisol levels were evident in the LD during the descending limb after the high dose, but there were no cortisol increases in the HD (group×dose×time: F8,1504 =6.03; P<.001; Figure 3B). Session order did not affect the main results (F ≥ 3.20 for all; P < .001 for all). The magnitude of the group differences on alcohol response change scores was moderate, with effect sizes computed by Cohen’s dequaling0.47 for stimulation, 0.46 for like, 0.53 for want more, 0.53 for sedation, and 0.36 for cortisol.
