The aforementioned differences between the HD and the LD on stimulation, like, want more, sedation, and cortisol remained significant after controlling for sex, race, educational level, FH, and disinhibited personality. There were no significant effects of FH of alcoholism (F ≤ 1.27 for all; P ≥ .27 for all) or interactions of FH and drinking group (F ≤ 1.25 for all; P ≥.26 for all) or FH and sex (F ≤ 0.93 for all; P ≥.47 for all) on alcohol response measures. Exploratory analyses examining a narrower criterion for FH—ie, men with alcoholic fathers (n=14) vs men with negative FH (n=44)—also were not significant for most alcohol response measures, including stimulation, sedation, like, and cortisol (F ≤ 1.06 for all; P > .39 for all). However, there was a trend for an interaction in these men in ratings for want more (FH×dose×time, F=2.03, P=.06), which was driven by higher ratings during placebo for men with positive FH vs men with negative FH.
