The estimated heritability (h2) for the ASPD/CD phenotype was 0.56 ± 0.24 (p<0.01) and for ASPD was 0.76 ± 0.1 (p<0.002). Significant evidence for heritability was not found for the CD phenotype. Gender (p=0.00002 and 0.0009) and Age (p= 0.007, 0.06) accounted for 6%, and 5% of the variance observed for ASPD/CD, and ASPD, respectively. As seen in Figure 1 and Figure 2, several regions of interest were identified for the two significantly heritable phenotypes in a genome scan. Six areas were found with LOD scores of 2.0 or above. For ASPD a region on chromosome 13 at 19 cM, and for ASPD/CD on chromosome 1 at 256 cM, on chromosome 3 at 193 cM, on 4 at 66 cM, on 14 at 86 cM, 17 at 129 cM and 20 at 40 cM.
