Chunk #13 — METHODS AND MATERIALS — Gene set overlap

Source

De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.

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We used DNENRICH (42) (https://psychgen.u.hpc.mssm.edu/dnenrich/) to test whether OCD genes harboring de novo damaging mutations (89 genes; excluding two genes, TTN and CACNA1E, found to harbor de novo damaging variants in control subjects) were significantly enriched among previously reported genes identified in autism (ASD), schizophrenia (SCZ), developmental disorders (DD), Tourette’s disorder (TD), and intellectual disability (ID). Details about the gene lists and DNENRICH parameters are provided in the Supplemental Methods.