Chunk #14 — METHODS AND MATERIALS — Exploratory pathway and network analyses

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De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.

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To determine whether all genes harboring de novo damaging variants in OCD are enriched for specific biological pathways, we used the same gene list from our gene set overlap analysis (n=89) to identify the most significant canonical pathways, biological processes, and diseases suggested by MetaCore (Clarivate Analytics) and Ingenuity Pathway Analysis (IPA, Qiagen Bioinformatics). Details of the settings used for each of these tools is given in the Supplemental Methods.