Total DEGs in L neurons between BPD and control (combined up and down regulated DEGs) were annotated by multiple pathway analysis tools. GO analysis performed on all DEGs suggested that the group differences reflect enrichment of genes involved in metabolic processes, including macromolecule and cellular RNA metabolism and biosynthesis pathways. Also identified were pathways involving protein transport including post-Golgi vesicle mediated transport and Golgi to plasma membrane protein transport (Table 2). Many of the pathways found for the total DEGs were seen when up and down regulated DEGs were analyzed separately eg cilium assembly, metabolic processes (Table 2). Although the number of down-regulated genes was small (32 genes), GO analysis revealed cell cycle pathways (Table 2).
