We used LDSC to partition TUD-EUR h2SNP and examined the enrichment based on several functional genomic annotation models.92,93 In the baseline model, we examined 75 overlapping functional annotations comprising genomic, epigenomic and regulatory features. We also analyzed ten overlapping cell-type groups derived from 220 cell-type-specific annotations in four histone marks: methylated histone H3 Lys4 (H3K4me1), trimethylated histone H3 Lys4 (H3K4me3), acetylated histone H3 Lys4 (H3K4ac) and H3K27ac. Enriched cell-type categories were analyzed based on annotations obtained from H3K4me1-imputed, gapped peak data generated by the Roadmap Epigenomics Mapping Consortium.94 We removed multi-allelic and major histocompatibility complex region variants, and only report categories enriched after Bonferroni correction.
