We used the LDSC package to conduct cell type specific heritability analysis (https://www.nature.com/articles/s41588-018-0081-4). In this analysis, we applied stratified LD score regression on the TUD-EUR meta-analysis summary statistics with sets of specifically expressed genes in various tissues from GTEx95–97 to identify TUD-relevant tissues. We applied a conservative Bonferroni correction based on the number of tissues simultaneously tested (205 tissues tested, p<2.44E-04). We also used MAGMA v1.08 gene-property analysis of expression data from GTEx (54 tissue types) and BrainSpan (29 brain samples at different age) in FUMA v1.3.6a85 to test the relationships between tissue specific gene expression profiles and TUD-gene associations.
