Chunk #60 — Methods — PWAS/TWAS.

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

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Of the overlapping findings across independent TWAS or PWAS datasets, colocalization analysis (in FUSION45,102) was used to determine whether SNPs mediate the association with TUD via effects on gene and protein expression. A posterior colocalization probability (PP) of 80% was used to indicate a shared causal signal.