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Chunk #41 — Main Text — The Contribution of Rare Variants to Disease Risk

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The genetics of major depression.
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1,141, of which only 718 usedUtah families87NANA–D3S17523.81chr3:97,645,283-97,845,588–RMD 1,513; anxiety 1,141, of which only 718 usedUtah families87NANA–D7S5172.89chr7:4,397,915-4,598,292–RMD 1,513; anxiety 1,141, of which only 718 usedUtah families87NANA–D18S12703.75chr18:61,292,502-61,492,816–RMD 1,513; anxiety 1,141, of which only 718 usedUtah families87NANA–D15S5152.88chr15:43,497,354-43,697,543MaleRMD 1,513; anxiety 1,141, of which only 718 usedUtah families87NANA–D4S26312.6chr4:155,863,840-156,064,129MaleMcGuffin et al., 2005RMD 929DeNt41792970.94SCAND1S4503.03chr1:9,485,419-9,685,791FemaleRMD 929DeNt41792970.94SCAND12S16131.57chr12:107,538,542-107,738,864–RMD 929DeNt41792970.94SCAND13S1701.47chr13:81,009,094-81,209,378–RMD 929DeNt41792970.94SCAND1S26672.54chr1:11,386,961-11,587,307FemaleRMD 929DeNt41792970.94SCAND1S5082.19chr1:7,507,384-7,707,656FemaleRMD 929DeNt41792970.94SCAND12S16831.29chr12:106,085,479-106,285,844–RMD 929DeNt41792970.94SCAND15S10471.14chr15:81,041,079-81,241,425–RMD 929DeNt41792970.94SCAND15S9991.08chr15:86,145,362-86,345,589–Breen et al., 2011RMD 2,164DeNtNA2,41272.43SCAND3S15154.01chr3:6,311,334-6,511,566–RMD 2,164DeNtNA2,41272.43SCAND7S5131.91chr7:11,551,237-11,751,614–RMD 2,164DeNtNA2,41272.43SCAND11S9371.75chr11:77,754,318-77,954,608–RMD 2,164DeNtNA2,41272.43SCAND10S16531.6chr10:15,577,832-15,778,169–RMD 2,164DeNtNA2,41272.43SCAND1S4500.75chr1:9,485,419-9,685,791–RMD 2,164DeNtNA2,41272.43SCAND12S1613<1chr12:107,538,542-107,738,864–RMD 2,164DeNtNA2,41272.43SCAND15S9991.41chr15:86,145,362-86,345,589–RMD 2,164DeNtNA2,41272.43SCAND13S170<1chr13:81,009,094-81,209,378–Holmans et al., 2004RMD 809GenRED2971,03979.00DIGSD15S6523.73chr15:92,417,335-92,617,665–Holmans et al., 2007RMD 1,720; MD 28GenRED6562,17679.63DIGSD15S6523.05chr15:92,417,335-92,617,665–RMD 1,720; MD 28GenRED6562,17679.63DIGSD17S9744.77chr17:10,418,666-10,618,972MaleRMD 1,720; MD 28GenRED6562,17679.63DIGSD8S11063.49chr8:12,735,859-12,936,149MaleLevinson et al., 2007RMD 1,687GenRED6312,16179.00DIGSNA4.69chr15:92,600,000–Pergadia et al., 2011MD and smoking 220Australian/Finland11681056.79CIDID3S13044.14chr3:6,819,242-7,019,583–Middeldorp et al., 2009MDAustralian/Dutch13355861.12CIDIATA58E082.1chr17:19,426,481-19,426,503–MDAustralian/Dutch13355861.12CIDID8S5041.9chr8:917,443-1,117,767–MDAustralian/Dutch13355861.12CIDIGATA66D011.7chr2:66,951,054-67,151,286–Schol-Gelok et al., 2010Symptoms of MD 115Dutch ERF451,14471.3HADS-D and CES-Drs7152710.93chr2:57133160–Symptoms of MD 115Dutch ERF451,14471.3HADS-D and CES-Drs8904780.99chr2:64540177–Symptoms of MD 115Dutch ERF451,14471.3HADS-D and CES-Drs3721692.14chr5:3180951–Symptoms of MD 115Dutch ERF451,14471.3HADS-D and CES-Drs19652772.27chr11:134850365–Symptoms of MD 115Dutch ERF451,14471.3HADS-D and CES-Drs16881282.66chr19:3029918–The table summarizes information from linkage studies of major depression. Most studies are represented by more than one publication (reporting additional data, or more in-depth analyses), so the second column provides a study name to indicate which studies report on the same data sets. Studies used different inclusion criteria; these are summarized under the column headed phenotype where RMD is recurrent major depression, MD is major depression, BPD is bipolar disease. Where provided, the