Chunk #34 — What are the mechanisms by which cannabinoids cause transient psychotic symptoms? — Gamma-aminobutyric acid (GABA)

Source

Cannabis and psychosis/schizophrenia: human studies.

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yes

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In the hippocampus and neocortex, CB1Rs are present on axon terminals of cholecystokinin (CCK) containing GABA neurons that target the perisomatic regions of pyramidal cells [58, 111]. Activation of CB1Rs reduces GABA release, resulting in disinhibition of pyramidal cell activity.