Furthermore, these CCK-containing, CB1R-expressing GABA neurons are believed to play an important role in orchestrating pyramidal cell synchrony in the gamma (40 Hz) frequency range [96, 220, 230, 234]. Gamma oscillations are synchronized over long distances in the brain and are hypothesized to “bind” together sensory perceptions and to play a role in perceptual, memory, and attentional processes (reviewed in [236]), all of which are also altered in psychosis. Activation of CB1Rs located on GABAergic hippocampal neurons reduces GABA release [67, 112, 212] and this will disrupt the synchronization of pyramidal cell activity [80, 96, 236]. The latter would interfere with memory consolidation, and associative functions and normal gating mechanisms, eventually leading to psychotic symptoms. Both in vivo and in vitro studies have reported that the CB1R agonists disrupt neural synchrony (reduced power of 40 Hz oscillations) [79, 80, 188].
