For the 24-hour two-bottle choice test, pioglitazone (10 and 30 mg/kg), fenofibrate (50 and 150 mg/kg), GW0742 (10 mg/kg), tesaglitazar (1.5 mg/kg), and bezafibrate (25 and 75 mg/kg) were administered orally by gavage (p.o.). For the limited access drinking test, 30 mg/kg pioglitazone, 150 mg/kg fenofibrate, 10 mg/kg GW0742, 1.5 mg/kg tesaglitazar, and 75 mg/kg bezafibrate were tested. Individual mice were administered a single drug at one or two different dosages and were only used in one of the ethanol drinking tests. Drugs were purchased from Sigma-Aldrich (St. Louis, MO) or Tocris Bioscience (Minneapolis, MN). All drugs were freshly prepared as suspensions in saline with 4–5 drops of Tween-80 and administered once daily in a volume 0.05 ml/10 g of body weight 60 minutes before drinking experiments. Saline containing 4–5 drops of Tween-80 was administered to control groups. Single use, sterile Becton, Dickinson and Co. gavage needles (27.5 gauge; model #305109) were used. Drug doses and routes of administration were based on previously published in vivo studies in rodents (Nakajima et al., 2009; Stopponi et al., 2011; Wang and Namura,
