Dubois et al [7] reported 13 SNPs in as many regions as showing suggestive statistical evidence for association with celiac disease; all 13 SNPs were genotyped and analyzed in the current GWAS. Five of the suggestive SNP associations were subsequently replicated by Trynka et al. [10] and are among the 40 known celiac disease regions. We investigated the association results in the current GWAS at these eight suggestive SNP loci that have not been subsequently replicated to determine if there was evidence for association in this North American study. Of the eight previously suggestive but unreplicated SNPs, only SNP rs6806528 on chromosome 3p14.1 showed evidence for association in the current GWAS. The associated region spans a 100 kb LD block. The most significant association identified in this GWAS was at rs4075188 with a p-value of 0.0012; the same SNP showed a p-value of 3.75×10−5 in the Dubois et al. [7] study and was the most significantly associated SNP in the region in that study. Figure 1 shows the results for all 17 SNPs across the LD block that were analyzed
