Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
paper
Cited
Public
- Authors
- Garner, Chad; Ahn, Richard; Ding, Yuan Chun; Steele, Linda; Stoven, Samantha; Green, Peter H; Fasano, Alessio; Murray, Joseph A; Neuhausen, Susan L
- Year
- 2014
- Journal
- PloS one
- PMID
- 24999842
- DOI
- 10.1371/journal.pone.0101428
- PMCID
- PMC4084811
We performed a genome-wide association study (GWAS) of 1550 North American celiac disease cases and 3084 controls. Twelve SNPs, distributed across four regions (3p21.31, 4q27, 6q15, 6q25), were significantly associated with disease (p-value <1.0Γ10-7), and a further seven SNPs, across four additional regions (1q24.3, 10p15.1, 6q22.31, 17q21.32) had suggestive evidence (1.0Γ10-7 < p-value < 1.0Γ10-6). This study replicated a previous suggestive association within FRMD4B (3p14.1), confirming it as a celiac disease locus. All four regions with significant associations and two regions with suggestive results (1q24.3, 10p15.1) were known disease loci. The 6q22.31 and 10p11.23 regions were not replicated. A total of 410 SNPs distributed across the eight significant and suggestive regions were tested for association with dermatitis herpetiformis and microscopic colitis. Preliminary, suggestive statistical evidence for association with the two traits was found at chromosomes 3p21.31, 6q15, 6q25, 1q24.3 and 10p11.23, with future studies being required to validate the reported associations.
Association results for 17 SNPs from the current GWAS and the GWAS reported by Dubois et al. (REF) within the FRMD4B gene on 3p14.1.
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