Four regions showed suggestive evidence for association with celiac disease, with these regions having at least one SNP meeting suggestive evidence threshold and no SNPs showing significant association (Table 1). Two SNPs on 10p15.1, rs4558075 and rs10796045, provided suggestive evidence to the region, with the SNPs having p-values of 0.013 and 0.014, respectively, for replication. The analysis of the region carried out by Trynka et al. [10] provided significant evidence for a celiac disease locus at 10p15.1. On chromosome 1q24.3, two SNPs in strong linkage disequilibrium (LD) showed suggestive evidence for association with celiac disease; however the SNPs showed no evidence for association, or replication, in the Dubois et al. [7] study. In the Dubois study, SNP rs859637 at 1q24.3 position 170,974,795 showed suggestive evidence for association, with GWAS and follow-up study p-values of 8.15×10−5 and 5.68×10−3, respectively. Subsequent analysis of the region by Trynka et al. [10] identified two significant association signals across the approximately 300 kb region. The two SNPs shown in Table 1 (rs9286879 and rs2157453) mark one of the two signals reported by Trynka et al.
