of the region by Trynka et al. [10] identified two significant association signals across the approximately 300 kb region. The two SNPs shown in Table 1 (rs9286879 and rs2157453) mark one of the two signals reported by Trynka et al. [10]. SNP rs859665 at position 170,931,065 on 1q24.3 showed a p-value of 4.48×10−4 in the GWAS and is in very weak linkage disequilibrium with the two SNPs in the same region shown in Table 1 (D' = -0.404 and R 2 = 0.025 between rs2157453 and rs859665). The SNPs rs859665 and rs2157453 showed significant independent effects in a logistic regression model that included both SNPs. The lack of replication observed for the two 1q24.3 SNPs shown in Table 1 can likely be attributed to sampling variation and statistical chance. SNPs rs531930 and rs8081391 on chromosomes 6q22.31 and 17q21.32, respectively, showed no evidence for association in the Dubois et al. [7] study, indicating that these suggestive results were most likely due to statistical chance and are not marking a real celiac disease region.
