responses could be separated genetically. For example, animals carrying the NP6006 lesion at the X11L locus exhibited higher Dist and near normal sedation sensitivity, and animals carrying the EP2336 lesion at the Tsp42El locus exhibited an increase in ΔDist and essentially no sedation tolerance (Table S5). Furthermore, when tested at different ethanol doses, phenotypic covariation for individual strains did not always hold (e.g., see Fig. 7). Therefore, the locomotor and sedative effects of ethanol exposure have both common and distinct substrates that can be distinguished by genetic and pharmacologic means.
