We observed a broad distribution of locomotor activity and sedation sensitivity responses to ethanol among the surveyed strains (Fig. S4). To ascertain the relationship between the locomotor and sedative effects of ethanol exposure, we performed regression analyses. We found a moderate correlation between our 2 measures of behavioral plasticity, ΔDist and sedation tolerance (R2 = 0.269, p < 0.001; Fig. 3), and only mild correlations between Dist and both ΔDist (R2 = 0.109, p < 0.001) and sedation sensitivity (R2 = 0.149, p < 0.001). Additionally, a stronger correlation was observed between ethanol sedation sensitivity and sedation tolerance (R2 = 0.484, p < 0.001). Correlation of these measures is also dose dependent (Fig. 1), suggesting that some of the observed strain differences may be due to shifts in either the actual or perceived ethanol dose. However, all measures of ethanol responses could be separated genetically. For example, animals carrying the NP6006 lesion at the X11L locus exhibited higher Dist and near normal sedation sensitivity, and animals carrying the EP2336 lesion at the Tsp42El locus exhibited an increase in ΔDist and
