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Chunk #57 — What is the basis of individual vulnerability to psychotic outcomes with exposure to cannabinoids?

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Cannabis and psychosis/schizophrenia: human studies.
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Several other genes relevant to schizophrenia and the mechanism of action of cannabinoids will also need to be studied. For example, as discussed earlier, there are extensive interactions between endocannabinoid and GABA systems. Thus, whether there are any interactions between cannabis exposure and variations in genes that regulate GABA on the risk of psychosis will be important to study.