We also identify loci that are involved in cardiovascular development (GATA2, KIAA1462, FBN2, FN1 and HAND2) such as fibrillin 2 (FBN2) which overlaps in action with fibrillin 1 in development of the aortic matrix45–49. In addition, fibronectin expression is increased in hypertension and in atherosclerosis but it may also play a role in the development of the heart49–51.
