The importance of microvascular function is emphasised by the solute carrier transporters such as SLC14A2 encoding a urea transporter, which has previously been linked to autosomal dominant Streeten type orthostatic hypotensive disorder41 and BP response to nifedipine, a calcium channel blocker antihypertensive drug42. SLC8A1 encodes a sodium calcium exchanger expressed in cardiomyocytes which alters cardiac contractility and hypertrophy and shows abnormal BP in SLC8A1 transgenic mice43. Variants at SLC35F1 have previously been associated with resting heart rate and ventricular size which could contribute to BP elevation44.
