We identify several loci containing genes involved in vascular signalling and second messenger systems such as PDE5A and PDE10A35–37. The phosphodiesterase PDE5A hydrolyzes cyclic GMP and is inhibited by sildenafil which leads to vasodilatation38. This finding fits with our previous discoveries of a role for gene loci encoding elements of natriuretic peptide-nitric oxide pathway and guanylate cyclase signalling systems in BP regulation18,39,40. Our findings strengthen the case for evaluating the opportunity to repurpose PDE5A inhibitors for use in hypertension.
