We partnered with the investigators of an ongoing large-scale GWAS of major depressive symptoms (N = 368,890) to follow up on the associations identified in the depressive symptoms and neuroticism analyses. The participants of the study were all European-ancestry customers of 23andMe, a personal genomics company, who responded to online survey questions about mental health. We did not request results for the SNPs identified in the subjective well-being or proxy-phenotype analyses, since these were both conducted in samples that overlap with 23andMe’s depression sample. For details on association models, quality-control filters, and the ascertainment of depression status, we refer to the companion study21. The p-values we report are based on standard errors that have been inflated by the square by the intercept from an LD score regression10.
