To evaluate the predictive power of a polygenic score derived from the subjective well-being meta-analysis results, we used two independent hold-out cohorts: the Health and Retirement Study (HRS41) and the Netherlands Twin Register (NTR42,43). To generate the weights for the polygenic score, we performed meta-analyses of the pooled subjective well-being phenotype excluding each of the holdout cohorts, applying a minimum-sample-size filter of 100,000 individuals (Supplementary Note). The results from these analyses are reported in Supplementary Table 33 and depicted in Supplementary Figure 15.
