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Chunk #12 — Results — GWAS meta-analyses

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Item-level analyses reveal genetic heterogeneity in neuroticism.
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In studying overlap in genetic signal between the 13 phenotypes (Methods; Supplementary Note 1), sign concordance tests showed that effect signs of top SNPs were largely concordant across the 13 phenotypes (Supplementary Fig. 20; Supplementary Data 31). However, Fisher’s exact tests revealed that the exact top SNPs overlapped only moderately between the 13 phenotypes (Supplementary Fig. 21; Supplementary Data 32), indicating that the most strongly associated SNPs differed considerably between individual measures.