gene has been related to the development of speech and language [28], yet is also implicated in a wide range of other traits and diagnoses [29] (see Fig. 1d). MAGMA generalized gene-set and tissue-specific gene-set analyses (sex-combined) yielded no significant gene-sets after Bonferroni-correction for multiple testing. The top gene-set for generalized gene-set analysis was activated NTRK2 signals through RAS signaling pathway (Supplementary Table 7), while the top tissue-specific gene expression was the hypothalamus (Supplementary Table 8). We next ran sex-specific GWAS meta-analyses. These analyses did not identify SNPs that reached genome-wide significance (Supplementary Tables 4 and 5).
