canSAR now includes expert curated and standardised drug combination data for 1456 clinical trials and over 316 000 drug synergies from cancer cell line models from our curated, canSynergize database (drug combination data available for download from cansarblack.icr.ac.uk/resources/cansynergize/cansynergize_latest.zip). This canSAR resource is complementary to other drug combination databases such as DrugComb (25), introducing over 100 novel published cell line-based drug combination studies, as well as exclusive clinical trials-based evidence for drug combinations. It focuses on experimentally observed drug-target associations (through curation of mechanism of action and stringent biochemical assay activity cut offs), and enables simultaneous assessment of drug combination evidence across a large number of targets using the canSAR interactome. canSAR uniquely contains 223 588 drug combination synergy measurements from cellular studies and a further 1456 from clinical trials that are not available in any other public resource.
