Furthermore, only when a discovery finding was replicated and confirmed by multiple groups, it was taken as “significant” in the present study. For these replicable findings, a region-wide correction might be sufficient. Five independent markers, which were the effective number capturing the information content of all 30 replicable risk markers in whole PHF3-PTP4A1 region ( Table 1 ), were predicted by the program SNPSpD [14]. Thus, a region-wide corrected α could be set at 0.01 ( = 0.05/5) for those replicable findings.
