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Chunk #11 — Materials and Methods — Phenotypic measures

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Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample.
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We examined two measures related to alcohol use and related psychopathology. First, we computed an index of drinking behaviors by taking the sum of four items drawn from a customized form of the Substance Abuse Module (SAM), an expansion to the World Health Organization’s Composite International Diagnostic Interview (Robins et al., 1987). These were 1) frequency of alcohol use over the prior 12 months, 2) average number of drinks consumed per alcohol use occasion over the prior 12 months, 3) maximum number of alcoholic drinks ever consumed in a 24 hour period, and 4) lifetime number of times ever having been intoxicated (the original text of all items is reproduced in the supplementary material). The four items were each scaled to an approximately common metric before being summed (scaling for each item is described in the supplementary material). . Cronbach’s alpha was 0.86 for the drinking index. Our second measure was a lifetime count of DSM-IIIR alcohol abuse and dependence symptoms, ascertained in the course of a structured clinical diagnostic interview (MCTFR clinical assessments are described in more detail in