Average PRS in each group as well as separated by AUD cases and controls were summarized in Table 2. FH+ individuals had higher PRS than individuals in the FH? and FH− subsamples; and FH? had higher PRS than FH−. AUD cases had higher PRS than controls in all four groups of individuals and the differences were significant in the full sample, FH+, and FH? (P-values≤1.85E-05) but not in FH− (P-value=0.31) subsamples. Table 3 shows the average PRS in individuals of different DSM-5 diagnostic criterion count. Overall, with the increase of DSM-5 AUD diagnostic criterion count, PRS increased. Again, all were significant (P-values≤2.09E-06) except in FH− (P-value=0.89).
