Having a first-degree family history of AUD was a significant indicator for AUD risk (OR=2.99, P-value=1.67E-13). PRS was also associated with AUD in the COGA full sample (OR=1.96, P-value=7.57E-08) and in the FH+ subsample (OR=1.86, P=value=1.32E-04) (Table 4). In FH?, while the continuous PRS was significantly associated with AUD (Beta=2.91, SE=0.60, P-value=1.51E-06), the dichotomized PRS (top decile vs remaining 90%) was not (P-value=0.06). Table 5 shows the association results between PRS and DSM-5 AUD diagnostic criterion count. Increasing PRS were significantly associated with greater DSM-5 AUD diagnostic criterion count (P-values≤6.04E-16) except in FH− (P-value=0.05).
