Table 3 shows that buprenorphine treatment days were associated with 37% lower odds of drug-related poisoning (95% confidence interval: 0.60–0.66) relative to non-treatment days, whereas odds of poisoning increased 81% on days when individuals were treated with benzodiazepines or Z drugs (1.73–1.91, Model 1). When we evaluated benzodiazepines and Z drugs separately, Z drug treatment days were associated with increased odds of poisoning events (OR=1.29 [1.19–1.39]), but this was notably lower than the odds associated with benzodiazepine treatment days (OR=1.88 [1.78–1.98], Model 2). We found no association between SSRI treatment days and drug-related poisonings (OR=0.95 [0.90–1.00], Model 3). We observed no difference in magnitude of protective effect against poisoning conferred by buprenorphine treatment days when conducting stratified analyses among benzodiazepine or Z drug users (OR=0.64 [0.60–0.69], Model 4) and those who never used benzodiazepine or Z drugs during the study’s observation period (OR=0.64 [0.59–0.69], Model 5).
