Meta-analysis was performed for the selected 11 SNPs by combining the results from the discovery and replication samples. Three meta-analyses were performed: (1) KAR-E + EA, (2) KARE + AA, and (3) KARE + EA + AA. Among the 11 replicated SNPs, 10 provided concordant direction of genetic effects, and one (rs10511914) showed discordant direction of effect for SI. All four replicated SNPs provided concordant direction of effects. The results are summarized in Table 4. Through meta-analysis, only 1 SNP rs848353 reached genome-wide significance (p = 9.16 × 10—8). In general, the meta-analysis of KARE + AA decreased the p value for rs848353. For the remaining three SNPs tested, however, meta-analysis did not reduce the p values enough to reach a genome-wide significance level.
