Chunk #56 — 6. ALCOHOL-ASSOCIATED CHANGES IN GENE/PROTEIN EXPRESSION OF P RATS — 6.3 Expression Differences for Glutamate Transporters, Enzymes, and Postsynaptic Density (Table 3)
In the adult CeA, operant ethanol self-administration upregulated Homer1 expression levels by over two-fold; although operant ethanol self-administration also downregulated Homer2 expression by ~20%, relative to controls.214 This latter result is peculiar given that chronic free-choice access to ethanol upregulates CeA Homer2 protein expression in P rats180 and C57BL/6J mice;85 which, again, may be due to nonpharmacologic factors related to the operant-conditioning procedures employed in the mRNA study.
