Chunk #57 — 6. ALCOHOL-ASSOCIATED CHANGES IN GENE/PROTEIN EXPRESSION OF P RATS — 6.3 Expression Differences for Glutamate Transporters, Enzymes, and Postsynaptic Density (Table 3)
Glycine transporter expression levels in the adult AcbSh were higher and glutamate transporter expression levels were lower in P rats compared to NP rats.211 Additionally, whenever ethanol intake modified membrane glutamate transporter expression levels, once each in the adult or adolescent CeA and multiple times in the adolescent DRN, it was always for an increase relative to control levels.208,213 However, when examining vesicular glutamate transporter expression levels, Vglut1 was increased by five-fold, whereas Vglut2 and Vglut3 were reduced by ~two-fold in the DRN following peri-adolescent binge-like drinking.213 Also, in the adult AcbShVglut2 expression levels were more than two-fold higher than that seen in NP rats.211
