We expected that DSM-NicDep would be more genetically correlated with psychopathology than FTND, as has been found in clinical and epidemiological studies (Breslau & Johnson, 2000). The point estimates of our genetic correlation analysis suggested that PTU (CPD + FTND) was the least associated with most indices of psychopathology, while both DSM-NicDep and ICD-TUD were more strongly associated with psychosocial indices. DSM-NicDep appeared to additionally index material deprivation more strongly than the other traits, while all four tobacco GWASs (DSM-NicDep, ICD-TUD, FTND, and CPD) were equivalently related to respiratory (e.g. FEV1 and lung cancer) and metabolic markers of tobacco exposure.
