Association also observed in the 50 K GWAS in the same publication. Three SNPs in the gene are among the highest-ranking 260 in the analysisrs2281597185.41E-071p35.134132445In intron of CSMD2 Encodes CUB and Sushi multiple domains 2, a protein with a potential role in cell adhesion and neurogenesis. Intermediate expression in fetal brain, adult brain, spinal cord, and all specific adult brain regions examined. Lower levels were detected in spleen, lung, and testis, and little to no expression was detected in the other tissues examined. The protein product is enriched in axonal growth cones and is involved in neuronal outgrowth during formation of neuronal circuits (Lesch et al. 2008). CSMD2 and its homologue CSMD1 have been found associated with addiction-related phenotypes in multiple GWAS (Uhl et al. 2008a)rs2502731191.58E-069q34.11130016378In intron of DNM1 Encodes dynamin 1, a GTPase involved in clathrin-mediated endocytosis and other vesicular trafficking processes, especially during high levels of neuronal activity. The finding lies close to linkage regions for autism (Szatmari et al. 2007 b).rs412050235.83E-0622q11.2220637519Immediately downstream of PPM1F The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Calcium/calmodulin-dependent protein
