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Chunk #49 — Review

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Genome-wide association studies in ADHD.
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The finding lies close to linkage regions for autism (Szatmari et al. 2007b) and major depressive disorder (Holmans et al. 2007)rs7175404146.03E-0715q26.191837692In intron of AK094352 Gene of unknown function. The finding lies close to linkage region for major depressive disorder (Holmans et al. 2007)rs10983238151.37E-079q33.1118373504In intron of ASTN2 Encodes astrotactin 2, a membrane protein expressed in multiple tissues including brain. It is critically involved in neuron-glia binding during the developmental periods of glial-guided cell migration and assembly into neuronal layers in the developing brain (Lesch et al. 2008). A homologue of the gene, ASTN, is involved in neuronal migration (Vrijenhoek et al. 2008).The gene was found disrupted by rare CNVs in schizophrenia patients (Vrijenhoek et al. 2008) and patients with autism (Marshall et al. 2008) shows association in GWAS of multiple addiction-related traits (Uhl et al. 2008a), as well as of schizophrenia (Sullivan et al. 2008)Also lies within suggestive linkage region for ADHD reported in the same publication (Lesch et al. 2008). Association also observed in the 50 K GWAS in the same publication. Three SNPs in the gene are among the highest-ranking 260 in the analysisrs2281597185.41E-071p35.134132445In intron of CSMD2 Encodes CUB and Sushi multiple domains 2, a protein with a potential